EVENTO
Mathematical modeling of CAR-T cell immunotherapy
Tipo de evento: Seminário de Avaliação - Série A
Chimeric Antigen Receptor (CAR)-T cell immunotherapy represents a great advance in thefight against cancer. This therapy aims to increase the ability of T lymphocytes to recognizeand kill tumor cells that express specific antigens. This improvement is due to the geneticmodification of these cells, through the insertion of the antigen-specific CAR gene. Despiteexpressive complete response rates, many patients still suffer a relapse and/or becomeresistant to therapy within the first few years. These barriers that prevent the effectivesuccess of the therapy are not completely understood but are related to patient-specificand product heterogeneity and antigen escape, among other issues. In this research project,the main focus is to study CAR-T immunotherapy responses against hematological cancers.Our goal is to develop mathematical models for both immunodeficient mice and patients,contributing to the advancement of preclinical and clinical research and to obtain moreadequate clinical markers to evaluate the results of the therapy. Specifically, we considerpatients with different hematological malignancies and we will study their responses tothe CAR-T therapy in the presence of patient-specific and product heterogeneity. Issuesrelated to resistance to therapy will also be investigated. In this way, our developmentscan be used as accessory tools for in silico experiments that can contribute to optimizingexperimental research. A step towards this aim has been accomplished by developing theCARTmath, an in silico platform for preclinical studies. Overall, the developed modelsmay help to shed light on the structure of the treatment and better understanding thechallenges that remain in the study of CAR-T cell immunotherapy.Para assistir acesse:meet.google.com/ofr-ohbp-oaj
Data Início: 24/11/2022 Hora: 14:00 Data Fim: 24/11/2022 Hora: 17:00
Local: LNCC - Laboratório Nacional de Computação Ciêntifica - Virtual
Aluno: Emanuelle Arantes Paixão - - LNCC
Orientador: Artur Fassoni - Universidade Federal de Itajubá - Luciana Carvalho Barros - - Regina Célia Cerqueira de Almeida - Laboratório Nacional de Computação Científica - LNCC
Participante Banca Examinadora: Abimael Fernando Dourado Loula - Laboratório Nacional de Computação Científica - LNCC Leonardo Chicaybam Peixoto - - FIOCRUZ Luciane Prioli Ciapina - Laboratório Nacional de Computação Científica - LNCC Regina Célia Cerqueira de Almeida - Laboratório Nacional de Computação Científica - LNCC
Suplente Banca Examinadora: Sandra Mara Cardoso Malta - Laboratório Nacional de Computação Científica - LNCC
